Sam & Max for the original Gameboy?
It EXISTS!
...I'm just kidding, it's just a contest where people mockup the games of today in full Original Gameboy glory. Here's a link to the contest.
Someone even made a Psychonauts one:
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Personal fave is the Cave Story one:
Actually, all the entries are well done...! All I can say is "wow".
I've tried it a few times, I don't have the patience or the skill to really get past anything really basic though. When I see things like this, it's amazing.
Isn't Photoshop a bit of an overkill? I'd say it's all skill and basically any image editing program, as long as you can make pixel dots in various colors. In fact, you don't even need a PC to make some pixel art. Check out this neat Post-it composition.
If you want more of these, just search the web for "Post-it art" and you'll find tons of pixly images.
P.S. - Check out this ultimate piece of Post-it / pixel art. Just click the image to open the webpage with more photos.
http://www.yikes.com/~pengo/8bit/
they had a whole page article.